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Sukralose er kjent under merkenavnet Splenda og er 400–800 ganger søtere enn sukrose (sukker). Sukralose fremstilles av vanlig sukker som gjennomgår en kjemisk prosess.

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Sucralose was discovered in 1976 by scientists from Tate & Lyle, working with researchers Leslie Hough and Shashikant Phadnis at Queen Elizabeth College (now part of King's College London).[6] The duo were trying to test chlorinated sugars as chemical intermediates. On a late-summer day, Phadnis was told to test the powder. Phadnis thought that Hough asked him to taste it, so he did.[6] He found the compound to be exceptionally sweet (the final formula was 600 times as sweet as sugar). They worked with Tate & Lyle for a year before settling down on the final formula.

Sitat:

It is manufactured by the selective chlorination of sucrose (table sugar), in which three of the hydroxyl groups are replaced with chlorine atoms to produce sucralose.